The bioethics committee survives only as long as the substrate of disease keeps producing victims faster than the regulator can review the cure. VERVE-102 is a lipid nanoparticle that walks into a hepatocyte, swaps a single base in the PCSK9 gene, and drops LDL cholesterol 59% in the top dose cohort from a single infusion. The HEART-2 numbers are small but the mechanism is final. A statin is a daily ritual whose adherence curve melts inside five years across any real population. Base editing of PCSK9 is a one-shot rewrite of the variable that decides whether arteries stiffen on schedule or not. The precautionary frame insists the danger is permanence. The mathematics insists the danger was always the iteration. Every cohort that clears 28-day follow-up converts another decade of statins-and-stents civilization into the museum exhibit it has been waiting to become. The committee's authority dissolves the moment a single infusion outperforms forty years of compliance theatre. Heart disease was the first mass killer the precautionary regime was built around. It will be the first retired by a delivery system that does not require permission to keep working.